This mod should be compatible with almost all other mods. It only adds a few enchantments and buffs/mods item statistics and, aside from making disenchantment possible, little else. It should therefore be compatible with all mods except those that change these same stats. This mod is save game compatible; no need to start a new playthru. Any issues can likely be fixed by altering your load order. As with any modded game, you can either put this mod lower so that it overwrites the changes of your other mods, or put this higher, so other mods overwrite it. If you have a lot of mods installed, its always a good idea to create a merged or bashed patch.